Combination of reverse transcription (RT) and deep sequencing has emerged as a powerful instrument for the detection of RNA modifications, a field that has Meat Grinders seen a recent surge in activity because of its importance in gene regulation.Recent studies yielded high-resolution RT signatures of modified ribonucleotides relying on both sequen
Recombinant Expression and Stapling of a Novel Long-Acting GLP-1R Peptide Agonist
Owing to their pleiotropic metabolic benefits, glucagon-like peptide-1 receptor (GLP-1R) agonists have been successfully utilized for treating metabolic diseases, such as type 2 diabetes and obesity.As part of our efforts in developing long-acting peptide therapeutics, we have previously reported a peptide engineering strategy that combines peptide
Anti-fibrotic activity of a rho-kinase inhibitor restores outflow function and intraocular pressure homeostasis
Glucocorticoids are widely used as RPM Sensor an ophthalmic medication.A common, sight-threatening adverse event of glucocorticoid usage is ocular hypertension, caused by dysfunction of the conventional outflow pathway.We report that netarsudil, a rho-kinase inhibitor, decreased glucocorticoid-induced ocular hypertension in patients whose intraocul
Multivariate Stochastic Optimization Approach Applied in a Flux-Cored Arc Welding Process
One of the main goals in flux-cored arc welding processes is the optimization of bead geometry, in which multiple geometric characteristics of the welding bead are important; therefore, multiobjective optimization programming is often applied.However, several optimization problems that Art for Kids use stochastic programming do not consider the imp